| Expression pattern: |
DN |
| Associated gene: |
USP28, c-Myc, FBXW7alpha |
| Associated microRNA: |
- |
| Biological function: |
represses glioma tumorigenesis by inhibiting proliferation and inducing G1 phase arrest (via its encoded protein FBXW7-185aa) |
| Molecular mechanism: |
circ-FBXW7 encodes FBXW7-185aa; FBXW7-185aa binds USP28, antagonizes USP28-induced c-Myc stabilization, and facilitates FBXW7alpha-mediated c-Myc degradation |
| Biological pathway or process: |
proliferation (inhibits); cell cycle (inhibits); ubiquitination (promotes) |
| Detected method: |
Q
S
|
| Validation methods: |
RNA-seq; RT-qPCR; Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; Sanger Sequencing; Northern Blot; FISH / smFISH; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; Transfection; MTT; EdU Staining; Cell Cycle Assay; In Vivo Animal Model; H&E Staining; Survival Analysis; Luciferase Reporter Assay; Co-IP; RNA Pull-Down; Western Blot |
| Clinical significance: |
circ-FBXW7 is decreased in glioblastoma tissues and higher circ-FBXW7 is associated with longer overall survival |
| Description: |
circ-FBXW7 (hsa_circ_0001451) is down-regulated in glioblastoma/glioma tissues. It encodes the protein FBXW7-185aa, which suppresses glioma cell proliferation and cell-cycle progression by binding USP28, antagonizing USP28-mediated c-Myc stabilization, and facilitating FBXW7alpha-dependent c-Myc degradation; higher circ-FBXW7 is associated with better overall survival. |
| Confidence score: |
0.8689 |