| Expression pattern: |
UP |
| Associated gene: |
KIAA0101, Ago2 |
| Associated microRNA: |
miR-638 |
| Biological function: |
promotes cell proliferation and migration and invasion in NSCLC cells |
| Molecular mechanism: |
Acts as a ceRNA/miRNA sponge for miR-638 to positively regulate KIAA0101 expression, promoting proliferation and migration. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; RNase R Treatment; Actinomycin D / DRB Stability Assay; FISH / smFISH; RIP (RNA Immunoprecipitation); RNA Pull-Down; Luciferase Reporter Assay; Transfection; CCK8; Transwell Assay; Clinical Sample Validation; Cohort Study; Survival Analysis; ROC Analysis; Western Blot; IHC (Immunohistochemistry); Bioinformatics Analysis |
| Clinical significance: |
High circTADA2A expression is associated with lymph node metastasis, advanced TNM stage, poorer overall survival, and has diagnostic value by ROC analysis. |
| Description: |
circTADA2A is upregulated in NSCLC tissues and cell lines and promotes NSCLC cell proliferation, migration, and invasion. Mechanistically, it mainly localizes to the cytoplasm and acts as a miR-638 sponge to increase KIAA0101 expression, forming a circTADA2A/miR-638/KIAA0101 ceRNA axis. Clinically, higher circTADA2A is associated with advanced disease features and poorer overall survival, with ROC-supported diagnostic potential. |
| Confidence score: |
0.8823 |