circRNA basic information
circBase ID: hsa_circ_0043278
Name: hsa_circ_TADA2A
Synonym: -
Host Gene: TADA2A
Genomic location(hg19): chr17:35797838-35800763:+
Genomic location(hg38): chr17:37437737-37440662:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005184
MONDO name: pancreatic ductal adenocarcinoma
Disease details: pancreatic ductal adenocarcinoma
Disease DO ID:
 3498, 3587
Disease MeSH ID:
 D021441
Disease NCIt ID:
 C9120
Disease ICD11 ID:
 581089833
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

pancreatic tissues; PDAC tissues; normal pancreatic tissues; paracancerous tissues
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: THBS1, FN1, TGFB2, ITGA1, ITGA3, TIMP3, BIRC3, COL4A1, LAMA4, MET, VASP, E2F1, FSCN1, NOTCH3, PDCD4, PIM1, SERPINB5, TWIST1, TPM2, TPM4, F3
Associated microRNA: hsa-mir-1, hsa-mir-214, hsa-mir-224, hsa-mir-223, hsa-mir-1305, hsa-mir-375
Biological function: May play important roles in PDAC progression (bioinformatics prediction).
Molecular mechanism: Competing endogenous RNA (ceRNA) network (circRNA-miRNA-mRNA).
Biological pathway or process:

ceRNA regulation (other); invasion (other); metastasis (other); EMT (other)
Detected method:
M
Validation methods:

Microarray; Bioinformatics Analysis
Clinical significance:

-
Description:

hsa_circ_0043278 is up-regulated in PDAC microarray datasets and was included in a predicted circRNA-miRNA-mRNA ceRNA network. The study suggests it may contribute to PDAC progression, but provides no experimental validation beyond bioinformatics/microarray analyses.
Confidence score:

0.1768
Other information
Title:

Integrated analysis of circular RNA-associated ceRNA network in pancreatic ductal adenocarcinoma.

Journal: Oncology letters
Published: 2020
PubMed ID: 32194715
Study type:

bioinformatics study
Data availability: GSE69362; GSE79634; GSE60980
Code availability: -