| Expression pattern: |
UP |
| Associated gene: |
relA, RELA, nos2, cxcl2, Bcl-2 |
| Associated microRNA: |
miR-1270 |
| Biological function: |
promotes Cryptosporidium parvum propagation (infection burden) in vitro; activates NF-kappaB pathway; inhibits apoptosis (via increasing Bcl-2) |
| Molecular mechanism: |
ceRNA/miRNA sponge mechanism: ciRS-7 sponges miR-1270 to upregulate relA (p65), activating NF-kappaB signaling and downstream genes (nos2, cxcl2), promoting parasite propagation |
| Biological pathway or process: |
NF-kappaB (promotes); apoptosis (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; Transfection; Luciferase Reporter Assay; Western Blot; Bioinformatics Analysis |
| Clinical significance: |
- |
| Description: |
In C. parvum-infected HCT-8 cells, ciRS-7 is up-regulated and functions as a miRNA sponge for miR-1270. Through the ciRS-7/miR-1270/relA (p65) ceRNA axis, it activates NF-kappaB signaling (including nos2 and cxcl2) and promotes parasite propagation, with evidence also suggesting an anti-apoptotic effect via increased Bcl-2. |
| Confidence score: |
0.5495 |