circRNA basic information
circBase ID: hsa_circ_0008360
Name: hsa_circ_XPNPEP3
Synonym: -
Host Gene: XPNPEP3
Genomic location(hg19): chr22:41277773-41278181:+
Genomic location(hg38): chr22:41277773-41278181:.
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0008383
MONDO name: rheumatoid arthritis
Disease details: rheumatoid arthritis
Disease DO ID:
 7148
Disease MeSH ID:
 D001172
Disease NCIt ID:
 C2884
Disease ICD11 ID:
 576319925
Disease OMIM ID:
 180300
Species: Human
Species details: Homo sapiens
Tissue specimen:

peripheral blood mononuclear cells / PBMCs
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: -
Associated microRNA: -
Biological function: May serve as a potential diagnostic biomarker for RA; negatively correlated with silk time and CCP.
Molecular mechanism: circRNA-miRNA co-expression network predicted by CircInteractome; specific miRNA targets not reported for this circRNA.
Biological pathway or process:

not specified
Detected method:
Q
S
Validation methods:

RNA-seq; RNase R Treatment; RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis
Clinical significance:

May serve as a potential biomarker for RA; negatively associated with silk time and CCP levels.
Description:

hsa_circ_0008360 is down-regulated in PBMCs from RA patients (RT-qPCR validated). Lower levels are negatively associated with silk time and CCP, supporting its potential biomarker relevance in RA.
Confidence score:

0.5135
Other information
Title:

RNA-seq reveals the circular RNA and miRNA expression profile of peripheral blood mononuclear cells in patients with rheumatoid arthritis.

Journal: Bioscience reports
Published: 2020
PubMed ID: 32191279
Study type:

combined biological and clinical study
Data availability: Supplementary Table S1; Supplementary Table S2
Code availability: -