circRNA basic information
circBase ID: hsa_circ_0087784
Name: hsa_circ_RNF20
Synonym: hsa_-circ_0087784
Host Gene: RNF20
Genomic location(hg19): chr9:104302484-104303257:+
Genomic location(hg38): chr9:101540202-101540975:+
Subcellular localization: cytoplasm
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005233
MONDO name: non-small cell lung carcinoma
Disease details: non-small cell lung cancer
Disease DO ID:
 3908
Disease MeSH ID:
 D002289
Disease NCIt ID:
 C2926
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

NSCLC tissue; tumor tissue samples; lung tissue
Cell lines:

A549; NCI-H1299; HCC1833; H1650; Beas-2B; Hcc1833; Luc-Hcc1833
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
UP
Associated gene: CDCA4
Associated microRNA: miR-576-5p
Biological function: Enhances NSCLC progression, tumor growth, proliferation, migration, invasion, lung metastasis, and EMT-related protein expression; silencing inhibits these malignant phenotypes.
Molecular mechanism: hsa_circ_0087784 acts as a miR-576-5p sponge to increase CDCA4 expression, forming the hsa_circ_0087784/miR-576-5p/CDCA4 regulatory loop.
Biological pathway or process:

proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); EMT (promotes); ceRNA regulation (promotes)
Detected method:
Q
H
Validation methods:

FISH / smFISH; RT-qPCR; Clinical Sample Validation; Luciferase Reporter Assay; Transfection; CCK8; EdU Staining; Transwell Assay; In Vivo Animal Model; IHC (Immunohistochemistry); H&E Staining; Western Blot; Bioinformatics Analysis
Clinical significance:

High hsa_circ_0087784 expression was associated with higher tumor grades and may be a potential therapeutic marker of NSCLC.
Description:

hsa_circ_0087784 is up-regulated in NSCLC tissues and cell lines and is mainly localized in the cytoplasm. It promotes NSCLC proliferation, migration, invasion, lung metastasis and EMT-associated protein expression by sponging miR-576-5p to increase CDCA4 expression. The hsa_circ_0087784/miR-576-5p/CDCA4 loop is proposed as a potential therapeutic marker for NSCLC.
Confidence score:

0.7373
Other information
Title:

Hsa_circ_0087784 enhances non-small cell lung cancer progression via the miR-576-5p/CDCA4 axis.

Journal: The American journal of the medical sciences
Published: 2025
PubMed ID: 39278405
Study type:

combined biological and clinical study
Data availability: The datasets used and/or analyzed during the current study are available from the corresponding author on reasonable request.
Code availability: -