| Expression pattern: |
UP |
| Associated gene: |
NEK2 |
| Associated microRNA: |
miR-329-3p |
| Biological function: |
Promotes glycolysis and radioresistance; promotes cell viability and clonogenic survival; promotes tumor growth in vivo; circPITX1 knockdown enhances radiosensitivity. |
| Molecular mechanism: |
Acts as a ceRNA to sponge miR-329-3p, thereby relieving repression of NEK2 and promoting glycolysis-associated factors (HIF-1alpha, HK2, LDH-A) and radioresistance. |
| Biological pathway or process: |
glycolysis (promotes); radioresistance (promotes); proliferation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Western Blot; Luciferase Reporter Assay; Transfection; MTT; Colony Formation Assay; In Vivo Animal Model; Bioinformatics Analysis; Clinical Sample Validation |
| Clinical significance: |
- |
| Description: |
circPITX1 is up-regulated in glioma tissues/cells and promotes glycolysis and radioresistance. Mechanistically, circPITX1 sponges miR-329-3p to increase NEK2 expression, enhancing glycolysis-associated protein expression and clonogenic survival; circPITX1 knockdown inhibits tumor growth in xenografts and increases radiosensitivity. |
| Confidence score: |
0.7164 |