| Expression pattern: |
UP |
| Associated gene: |
CBLL1 |
| Associated microRNA: |
miR-545-3p |
| Biological function: |
Promotes NSCLC malignant phenotypes and cisplatin (DDP) resistance (supports colony formation/cell cycle progression, metastasis; inhibits apoptosis/necrosis under DDP). |
| Molecular mechanism: |
Acts as a miRNA sponge for miR-545-3p to relieve repression of CBLL1. |
| Biological pathway or process: |
apoptosis (inhibits); cell cycle (promotes); migration (promotes); invasion (promotes); metastasis (promotes); EMT (promotes); chemoresistance (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Clinical Sample Validation; Nuclear-Cytoplasmic Fractionation; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Transfection; Colony Formation Assay; Cell Cycle Assay; Transwell Assay; Annexin V/PI Flow Cytometry; Western Blot; In Vivo Animal Model |
| Clinical significance: |
- |
| Description: |
circ_0072083 (circZFR) is up-regulated in NSCLC tissues/cells and mainly localized in the cytoplasm. It promotes malignant behaviors and cisplatin resistance by sponging miR-545-3p, thereby increasing CBLL1 expression; circ_0072083 depletion enhances DDP-induced growth inhibition and apoptosis in vitro and reduces xenograft tumor growth in vivo. |
| Confidence score: |
0.7635 |