circRNA basic information
circBase ID: hsa_circ_0025039
Name: hsa_circ_FOXM1
Synonym: -
Host Gene: FOXM1
Genomic location(hg19): chr12:2975558-2977920:-
Genomic location(hg38): chr12:2866392-2868754:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005105
MONDO name: melanoma
Disease details: melanoma
Disease DO ID:
 1909
Disease MeSH ID:
 D008545
Disease NCIt ID:
 C3224
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

melanoma tissues; adjacent normal tissues / normal skin tissues
Cell lines:

A2058; A375; HEMn
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
UP
Associated gene: FLOT2, Ago2
Associated microRNA: miR-143-3p
Biological function: promotes proliferation, invasion, glycolysis and tumor growth; inhibits apoptosis
Molecular mechanism: acts as a miRNA sponge (ceRNA) for miR-143-3p to upregulate FLOT2
Biological pathway or process:

proliferation (promotes); invasion (promotes); glycolysis (promotes); apoptosis (inhibits); ceRNA regulation (promotes)
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; Transfection; MTT; Annexin V/PI Flow Cytometry; Transwell Assay; Western Blot; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); In Vivo Animal Model
Clinical significance:

-
Description:

Circ-FOXM1 is up-regulated in melanoma tissues/cells and functions as an oncogenic circRNA. It sponges miR-143-3p to de-repress FLOT2, thereby promoting proliferation, invasion and glycolysis while inhibiting apoptosis, and it enhances tumor growth in a xenograft model.
Confidence score:

0.6825
Other information
Title:

Circ-FOXM1 contributes to cell proliferation, invasion, and glycolysis and represses apoptosis in melanoma by regulating miR-143-3p/FLOT2 axis.

Journal: World journal of surgical oncology
Published: 2020
PubMed ID: 32183822
Study type:

combined biological and clinical study
Data availability: The datasets used and/or analyzed during the current study are available from the corresponding author on reasonable request.
Code availability: -