| Expression pattern: |
UP |
| Associated gene: |
SLC38A6 |
| Associated microRNA: |
miR-1178-3p |
| Biological function: |
promotes proliferation; inhibits apoptosis |
| Molecular mechanism: |
circ_0110940 binds and suppresses miR-1178-3p, relieving repression of SLC38A6 by miR-1178-3p and thereby increasing SLC38A6 expression. |
| Biological pathway or process: |
proliferation (promotes); apoptosis (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Actinomycin D / DRB Stability Assay; Transfection; Luciferase Reporter Assay; Colony Formation Assay; EdU Staining; Annexin V/PI Flow Cytometry; Western Blot; Bioinformatics Analysis |
| Clinical significance: |
may provide basis for the targeted therapy of gastric cancer |
| Description: |
circ_0110940 is up-regulated in gastric cancer cell lines and functions as an oncogenic circRNA by promoting proliferation and inhibiting apoptosis. Mechanistically, it binds and suppresses miR-1178-3p, thereby increasing SLC38A6 expression (circ_0110940/miR-1178-3p/SLC38A6 axis). |
| Confidence score: |
0.6945 |