| Expression pattern: |
UP |
| Associated gene: |
Wnt2b, beta-catenin, c-Myc |
| Associated microRNA: |
miR-185-3p |
| Biological function: |
promotes proliferation, migration, invasion, tumorigenesis, metastasis and EMT in HSCC |
| Molecular mechanism: |
circ_0058106 directly binds (sponges) miR-185-3p, negatively regulates miR-185-3p, and activates Wnt2b/beta-catenin/c-Myc signaling to promote EMT and metastasis |
| Biological pathway or process: |
Wnt/beta-catenin (promotes); EMT (promotes); proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; Sanger Sequencing; FISH / smFISH; Nuclear-Cytoplasmic Fractionation; Luciferase Reporter Assay; Transfection; CCK8; Colony Formation Assay; EdU Staining; Transwell Assay; Wound Healing Assay; Western Blot; IHC (Immunohistochemistry); In Vivo Animal Model; H&E Staining; Bioinformatics Analysis; Clinical Sample Validation |
| Clinical significance: |
circ_0058106 may be a new therapeutic target and prognostic marker for HSCC |
| Description: |
circ_0058106 is up-regulated in HSCC tumor tissues and promotes proliferation, migration/invasion, tumorigenesis, metastasis and EMT. Mechanistically, it binds (sponges) miR-185-3p and upregulates the Wnt2b/beta-catenin/c-Myc pathway. |
| Confidence score: |
0.843 |