circRNA basic information
circBase ID: hsa_circ_0001946
Name: hsa_circ_CDR1AS
Synonym: circCDR1AS
Host Gene: -
Genomic location(hg19): chrX:139865339-139866824:+
Genomic location(hg38): chrX:140783174-140784659:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0008315
MONDO name: prostate cancer
Disease details: prostate cancer
Disease DO ID:
 10283
Disease MeSH ID:
 D011471
Disease NCIt ID:
 C7378
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

prostate puncture tissues; prostate tumor tissues; benign prostatic hyperplasia (BPH) tissues
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: -
Molecular mechanism: -
Biological pathway or process:

not specified
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; ROC Analysis
Clinical significance:

Potential diagnostic biomarker for distinguishing PCa from BPH (AUC 0.848; 92% sensitivity; 76% specificity).
Description:

circCDR1AS is up-regulated in prostate cancer tissue compared with BPH and shows diagnostic potential to distinguish PCa from BPH (ROC AUC 0.848).
Confidence score:

0.4187
Other information
Title:

Clinical values of expression signature of circCDR1AS and circHIAT1 in prostate cancer: Two circRNAs with regulatory function in androgen receptor (AR) and PI3K/AKT signaling pathways.

Journal: Journal of clinical laboratory analysis
Published: 2022
PubMed ID: 35007362
Study type:

clinical study
Data availability: All data are included in this article.
Code availability: -