| Expression pattern: |
DS |
| Associated gene: |
YTHDF2 |
| Associated microRNA: |
miR-766 |
| Biological function: |
Suppresses osteosarcoma cell proliferation, migration, invasion and in vivo tumor growth. |
| Molecular mechanism: |
Acts as a miRNA sponge (ceRNA) for miR-766 to relieve repression of YTHDF2. |
| Biological pathway or process: |
proliferation (inhibits); migration (inhibits); invasion (inhibits); metastasis (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
H
|
| Validation methods: |
RT-qPCR; ISH (In Situ Hybridization); Bioinformatics Analysis; Luciferase Reporter Assay; Transfection; CCK8; Colony Formation Assay; EdU Staining; Transwell Assay; Wound Healing Assay; Western Blot; IHC (Immunohistochemistry); In Vivo Animal Model; Survival Analysis; Cohort Study; Clinical Sample Validation |
| Clinical significance: |
Lower circ_0001105 expression is associated with poor prognosis and is an independent prognostic factor in osteosarcoma patients. |
| Description: |
The study reports that circ_0001105 suppresses osteosarcoma malignant behaviors (proliferation, migration/invasion and xenograft growth). Mechanistically, circ_0001105 functions as a ceRNA that sponges miR-766, thereby relieving miR-766-mediated repression of YTHDF2. |
| Confidence score: |
0.7739 |