| Expression pattern: |
DN |
| Associated gene: |
PI3K/AKT/mTOR signalling pathway |
| Associated microRNA: |
miR-21-5p |
| Biological function: |
protects HK-2 cells against I/R-caused injury by promoting cell viability/growth, reducing apoptosis, and suppressing inflammatory cytokine secretion and ROS generation |
| Molecular mechanism: |
circYAP1 sponges miR-21-5p, thereby activating the PI3K/AKT/mTOR pathway and alleviating I/R-induced injury |
| Biological pathway or process: |
PI3K/AKT/mTOR (promotes); apoptosis (inhibits); inflammation (inhibits); proliferation (promotes); oxidative phosphorylation (unclear); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Annexin V/PI Flow Cytometry; ELISA; Western Blot; Bioinformatics Analysis; Luciferase Reporter Assay |
| Clinical significance: |
- |
| Description: |
In AKI/I-R injury models, circYAP1 is down-regulated in patient whole blood and I/R-treated HK-2 cells. circYAP1 overexpression protects HK-2 cells by promoting viability, reducing apoptosis and inflammatory injury (cytokines/ROS) through sponging miR-21-5p and activating the PI3K/AKT/mTOR pathway. |
| Confidence score: |
0.6521 |