circRNA basic information
circBase ID: hsa_circ_0003575
Name: hsa_circ_CHMP5
Synonym: circular RNA 0003575
Host Gene: hsa-miR-148a-3p
 
 
 
Disease basic information
DO ID:
 1936
DO name: atherosclerosis
Disease details: atherosclerosis
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: peripheral blood mononuclear cells (PBMC)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DS
Associated gene: FOXO3, FOXO4
Associated microRNA: hsa-miR-148a-3p
Biological function: -
Molecular mechanism: miRNA sponge
Survival: -
Supported No.:
 3
Description:

We demonstrate that miR-148a-3p suppresses FOXO4 and FOXO3 expression via interruption of circ_0003575 function, which in turn impairs the proliferative and migratory function of endothelial cells, eventually exacerbating the atherosclerosis.
Other information
Title:

MicroRNA-148a-3p promotes survival and migration of endothelial cells isolated from Apoe deficient mice through restricting circular RNA 0003575.

Journal: Gene
Published: 2019/7/1
PubMed ID: 31255737