| Expression pattern: |
DN |
| Associated gene: |
SND1, MMP-2/9, CD44, p53, p21, caspase-3/8, HER3 |
| Associated microRNA: |
hsa-miR-184, hsa-miR-1276, hsa-miR-450b-3p |
| Biological function: |
promotes proliferation; inhibits migration |
| Molecular mechanism: |
Predicted ceRNA network in which hsa_circ_0021087 may act as an miRNA sponge for hsa-miR-184, hsa-miR-1276 and hsa-miR-450b-3p to regulate downstream mRNAs. |
| Biological pathway or process: |
proliferation (promotes); migration (inhibits); ceRNA regulation (other); PI3K/AKT (other); cell cycle (other) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; Bioinformatics Analysis; RT-qPCR; Clinical Sample Validation; ROC Analysis; Transfection; CCK8; Wound Healing Assay; Transwell Assay |
| Clinical significance: |
Plasma hsa_circ_0021087 is down-regulated in GC patients and differs between preoperative and postoperative stages; ROC AUC 0.7056 for distinguishing GC from controls; combined with hsa_circ_0005051 improves diagnostic accuracy. |
| Description: |
hsa_circ_0021087 is down-regulated in gastric cancer tissues/cells/plasma and shows postoperative rebound in plasma, supporting its use as a non-invasive diagnostic biomarker. Functionally, it promotes GC cell proliferation and its knockdown increases migration, and it is predicted to act via a circRNA-miRNA-mRNA ceRNA network involving miR-184/miR-1276/miR-450b-3p. |
| Confidence score: |
0.6719 |