| Expression pattern: |
UP |
| Associated gene: |
MAPK signaling pathway, p38, ERK, JNK |
| Associated microRNA: |
miR-223-3p |
| Biological function: |
circSnap47 promotes heart failure progression, OGD-induced H9C2 cell injury, apoptosis, and inflammation; silencing circSnap47 increases cell viability and inhibits apoptosis and inflammatory cytokine production. |
| Molecular mechanism: |
circSnap47 acts as a sponge for miR-223-3p and regulates the miR-223-3p/MAPK axis in heart failure. |
| Biological pathway or process: |
MAPK (promotes); apoptosis (promotes); inflammation (promotes); ceRNA regulation (other); other pathway/process (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
RT-qPCR; Bioinformatics Analysis; Luciferase Reporter Assay; Transfection; CCK8; TUNEL; ELISA; Western Blot |
| Clinical significance: |
circSnap47 may provide a new therapeutic direction for the treatment of heart failure. |
| Description: |
circSnap47 is up-regulated in heart failure-related datasets/tissues and in OGD-induced H9C2 cardiomyocytes. Functional knockdown experiments indicate that circSnap47 promotes OGD-induced cardiomyocyte injury, apoptosis, and inflammation. Mechanistically, circSnap47 acts through miR-223-3p and the MAPK signaling pathway, suggesting potential therapeutic relevance in HF. |
| Confidence score: |
0.5607 |