circRNA basic information
circBase ID: hsa_circ_0059665
Name: hsa_circ_ABHD12
Synonym: hsa_circRNA_059665
Host Gene: ABHD12
Genomic location(hg19): chr20:25288601-25300954:-
Genomic location(hg38): chr20:25307965-25320318:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0006515
MONDO name: acute pancreatitis
Disease details: acute pancreatitis
Disease DO ID:
 2913
Disease MeSH ID:
 -
Disease NCIt ID:
 C95437
Disease ICD11 ID:
 698285441
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

whole blood
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: -
Associated microRNA: hsa-miR-122, hsa-miR-148a
Biological function: Down-regulated in mild acute pancreatitis compared with healthy controls; proposed as a novel biomarker for molecular diagnosis/evaluation in AP.
Molecular mechanism: ceRNA network prediction; potential miRNA sponge (hsa-miR-122, hsa-miR-148a).
Biological pathway or process:

ceRNA regulation (other)
Detected method:
Q
M
Validation methods:

Microarray; RNase R Treatment; RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis
Clinical significance:

-
Description:

hsa_circRNA_059665 is down-regulated in whole blood from mild acute pancreatitis patients versus healthy controls and was confirmed by RT-qPCR after microarray screening. In the constructed ceRNA network, it is predicted to target miRNAs including hsa-miR-122 and hsa-miR-148a, suggesting a potential miRNA-sponge role without direct experimental validation of downstream targets.
Confidence score:

0.5135
Other information
Title:

Elevated hsa_circRNA_101015, hsa_circRNA_101211, and hsa_circRNA_103470 in the Human Blood: Novel Biomarkers to Early Diagnose Acute Pancreatitis.

Journal: BioMed research international
Published: 2020
PubMed ID: 32149089
Study type:

combined biological and clinical study
Data availability: included within the supplementary information file
Code availability: -