circRNA basic information
circBase ID: hsa_circ_0017586
Name: hsa_circ_GDI2
Synonym: -
Host Gene: GDI2
Genomic location(hg19): chr10:5815804-5842668:-
Genomic location(hg38): chr10:5773841-5800705:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0004986
MONDO name: urinary bladder carcinoma
Disease details: Non-Muscle-Invasive Bladder Cancer
Disease DO ID:
 4007
Disease MeSH ID:
 -
Disease NCIt ID:
 C4912
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

bladder cancer tissue
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UN
Associated gene: hsa_circ_0003221, hsa_circ_0001741
Associated microRNA: miR-103a-3p, miR-107
Biological function: Potential oncogenic function in bladder cancer via ceRNA activity (sponging miR-107).
Molecular mechanism: Predicted ceRNA mechanism via sponging miR-107 (and shared miR-103a-3p) in network module with other circRNAs.
Biological pathway or process:

ceRNA regulation (other)
Detected method:
S
Validation methods:

RNA-seq; Bioinformatics Analysis; ROC Analysis
Clinical significance:

Proposed as a novel potential circRNA related to NMIBC (candidate biomarker) from hub/altered genes in ceRNA networks.
Description:

This study computationally identified hsa_circ_0017586 (host gene GDI2) as a hub/altered circRNA potentially related to NMIBC. Network analysis suggested it may act via a ceRNA mechanism by sponging miR-107 (shared with hsa_circ_0003221 and hsa_circ_0001741).
Confidence score:

0.348
Other information
Title:

Detection of novel biomarkers for early detection of Non-Muscle-Invasive Bladder Cancer using Competing Endogenous RNA network analysis.

Journal: Scientific reports
Published: 2019
PubMed ID: 31182759
Study type:

bioinformatics study
Data availability: E-MTAB-4321
Code availability: -