| Expression pattern: |
UP |
| Associated gene: |
- |
| Associated microRNA: |
hsa-miR-135a/b, hsa-miR-543 |
| Biological function: |
May be involved in the development of acute pancreatitis and serves as a blood diagnostic biomarker; increases with disease severity and declines after treatment. |
| Molecular mechanism: |
ceRNA network prediction; potential miRNA sponge (e.g., hsa-miR-135a/b, hsa-miR-543). |
| Biological pathway or process: |
ceRNA regulation (other) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RNase R Treatment; RT-qPCR; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis |
| Clinical significance: |
Can be used as a blood biomarker to diagnose acute pancreatitis at early stage; diagnostic performance assessed by ROC (AUC 0.768 in MAP vs healthy). |
| Description: |
hsa_circRNA_101015 is up-regulated in whole blood of acute pancreatitis patients, increases with disease severity, and declines after treatment. It shows diagnostic value for early AP (ROC AUC reported) and is predicted in a ceRNA network to potentially sponge miRNAs (e.g., hsa-miR-135a/b and hsa-miR-543). |
| Confidence score: |
0.5963 |