circRNA basic information
circBase ID: hsa_circ_0066875
Name: -
Synonym: -
Host Gene: -
Genomic location(hg19): chr3:119222378-119232566:+
Genomic location(hg38): chr3:119503531-119513719:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005575
MONDO name: colorectal cancer
Disease details: colorectal cancer
Disease DO ID:
 5672, 9256
Disease MeSH ID:
 -
Disease NCIt ID:
 C4978
Disease ICD11 ID:
 -
Disease OMIM ID:
 114500
Species: Human
Species details: Homo sapiens
Tissue specimen:

colorectal adenoma tissue; CRC tissue; adjacent normal tissue
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: ADCY5, ALPK3, SDK1, MID2, TNS1, RBPMS, GNAZ, RRAS
Associated microRNA: hsa-miR-135b-5p
Biological function: May play roles in both colorectal adenoma and CRC and serve as an early predictive biomarker discriminating adenoma/CRC from adjacent normal tissues.
Molecular mechanism: ceRNA mechanism (miRNA sponging) by binding to hsa-miR-135b-5p to regulate multiple mRNAs.
Biological pathway or process:

ceRNA regulation (other)
Detected method:
Q
S
Validation methods:

RNA-seq; RT-qPCR; Bioinformatics Analysis; Clinical Sample Validation; ROC Analysis
Clinical significance:

ROC curve analysis identified hsa_circ_0066875 as a possible novel biomarker predicting the transition from colonic adenoma to cancer; it showed good diagnostic values for discriminating adenoma/CRC from adjacent normal tissues (AUC reported).
Description:

hsa_circ_0066875 is downregulated in both colorectal adenoma and colorectal cancer tissues versus adjacent normal tissues. It is predicted to act as a ceRNA by binding hsa-miR-135b-5p and potentially regulating targets including ADCY5, ALPK3, SDK1, MID2, TNS1, RBPMS, GNAZ and RRAS, and it shows diagnostic value for adenoma-to-cancer transition.
Confidence score:

0.5047
Other information
Title:

Comprehensive RNA Sequencing in Adenoma-Cancer Transition Identified Predictive Biomarkers and Therapeutic Targets of Human CRC.

Journal: Molecular therapy. Nucleic acids
Published: 2020
PubMed ID: 32145677
Study type:

combined biological and clinical study
Data availability: https://doi.org/10.1016/j.omtn.2020.01.031
Code availability: -