| Expression pattern: |
DN |
| Associated gene: |
STAT3 |
| Associated microRNA: |
miR-296-5p |
| Biological function: |
circNSUN2 promotes malignant development of CRC cells; its overexpression offsets Aloperine-mediated inhibition of proliferation and promotion of apoptosis, while circNSUN2 knockdown inhibits proliferation and promotes apoptosis. |
| Molecular mechanism: |
circNSUN2 acts as a miR-296-5p sponge to regulate STAT3; Aloperine suppresses circNSUN2, thereby increasing miR-296-5p and reducing STAT3 activity, leading to reduced proliferation and increased apoptosis. |
| Biological pathway or process: |
proliferation (promotes); apoptosis (inhibits); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis; Luciferase Reporter Assay; Transfection; MTT; EdU Staining; Colony Formation Assay; Annexin V/PI Flow Cytometry; Western Blot |
| Clinical significance: |
- |
| Description: |
In CRC cell lines, Aloperine suppresses circNSUN2, and circNSUN2 promotes malignant phenotypes by sponging miR-296-5p to support STAT3 signaling. Overexpression of circNSUN2 partially rescues Aloperine-induced inhibition of proliferation and promotion of apoptosis, confirming a circNSUN2/miR-296-5p/STAT3 regulatory axis. |
| Confidence score: |
0.6536 |