| Expression pattern: |
UP |
| Associated gene: |
p53, E-cadherin, N-cadherin, Vimentin, Bcl-2, Bax |
| Associated microRNA: |
miR-431 |
| Biological function: |
Promotes gastric cancer cell proliferation, migration and invasion; its knockdown suppresses tumorigenesis and inhibits EMT and affects p53-related protein expression. |
| Molecular mechanism: |
Acts as a miRNA sponge for miR-431, thereby modulating p53 expression and EMT signaling. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); EMT (promotes); p53 signaling (inhibits); apoptosis (inhibits) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Survival Analysis; Bioinformatics Analysis; Luciferase Reporter Assay; Transfection; CCK8; EdU Staining; Transwell Assay; Western Blot |
| Clinical significance: |
Higher circRNA_0005075 expression is associated with vascular invasion, advanced stage, lymph node metastasis and shorter overall survival in GC patients. |
| Description: |
circRNA_0005075 is up-regulated in gastric cancer and higher expression associates with worse overall survival. Functionally, its knockdown suppresses proliferation and metastasis of GC cells by sponging miR-431, leading to increased p53 and inhibition of EMT-related changes. |
| Confidence score: |
0.7113 |