circRNA basic information
circBase ID: -
Name: hsa_circ_ARID1A
Synonym: circARID1A
Host Gene: ARID1A
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: cytoplasm
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005258
MONDO name: autism spectrum disorder
Disease details: autism spectrum disorder
Disease DO ID:
 0060041
Disease MeSH ID:
 -
Disease NCIt ID:
 C88412
Disease ICD11 ID:
 437815624
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

postmortem cortex samples; frontal cortex (FC); temporal cortex (TC)
Cell lines:

NHA; SH-SY5Y; U118; ReNcell VM
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: NLGN1, STAG1, HSD11B1, VIP, UBA6
Associated microRNA: miR-204-3p
Biological function: Acts as a miRNA sponge for miR-204-3p and regulates ASD risk genes.
Molecular mechanism: ceRNA sponge mechanism: circARID1A binds miR-204-3p and relieves repression of target mRNAs including ASD risk genes.
Biological pathway or process:

ceRNA regulation (promotes)
Detected method:
Q
S
Validation methods:

RNA-seq; RT-qPCR; Back-Splice Junction PCR / divergent primers PCR; Sanger Sequencing; RNase R Treatment; Nuclear-Cytoplasmic Fractionation; Luciferase Reporter Assay; Transfection; Microarray; Bioinformatics Analysis; Clinical Sample Validation
Clinical significance:

-
Description:

circARID1A is up-regulated in ASD cortex and predominantly cytoplasmic. It sponges miR-204-3p, thereby modulating expression of multiple miR-204-3p target genes including ASD risk genes such as NLGN1, STAG1, HSD11B1, VIP, and UBA6.
Confidence score:

0.7561
Other information
Title:

Genome-wide, integrative analysis of circular RNA dysregulation and the corresponding circular RNA-microRNA-mRNA regulatory axes in autism.

Journal: Genome research
Published: 2020
PubMed ID: 32127416
Study type:

combined biological and clinical study
Data availability: syn4587609; GSE145417
Code availability: GitHub; Supplemental Code