| Expression pattern: |
UP |
| Associated gene: |
DNA damage inducible transcript 3 (CHOP) |
| Associated microRNA: |
- |
| Biological function: |
Promotes proliferation, migration, invasion and enhances multidrug resistance in NSCLC; inhibits CHOP expression. |
| Molecular mechanism: |
Enhances MDR by inhibiting CHOP expression in NSCLC cells. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); drug resistance (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; Bioinformatics Analysis; RT-qPCR; Clinical Sample Validation; Survival Analysis; Transfection; CCK8; Transwell Assay; Western Blot |
| Clinical significance: |
Higher circRNA_103762 expression in NSCLC patients was associated with lower survival rate. |
| Description: |
circRNA_103762 is up-regulated in NSCLC tissues and cell lines and is associated with worse overall survival. Functionally, its knockdown suppresses proliferation/migration/invasion and reduces multidrug resistance, at least partly by relieving inhibition of CHOP expression. |
| Confidence score: |
0.6719 |