| Expression pattern: |
UP |
| Associated gene: |
c-FLIP |
| Associated microRNA: |
miR-205-5p |
| Biological function: |
promotes proliferation, migration, invasion and EMT; facilitates invasion and metastasis in vitro |
| Molecular mechanism: |
ceRNA mechanism: circPVT1 sponges miR-205-5p to relieve repression of c-FLIP, promoting EMT |
| Biological pathway or process: |
EMT (promotes); proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Transfection; CCK8; Colony Formation Assay; Transwell Assay; Western Blot; Luciferase Reporter Assay; Bioinformatics Analysis; Clinical Sample Validation |
| Clinical significance: |
circPVT1 might be a potential therapeutic target for further clinical therapy of OS |
| Description: |
circPVT1 is up-regulated in osteosarcoma tissues and cell lines and promotes proliferation, migration, invasion and EMT in vitro. Mechanistically, it functions as a ceRNA by sponging miR-205-5p, thereby relieving miR-205-5p-mediated suppression of c-FLIP (circPVT1/miR-205-5p/c-FLIP axis). |
| Confidence score: |
0.6521 |