| Expression pattern: |
UP |
| Associated gene: |
MAPK1 |
| Associated microRNA: |
miR-940 |
| Biological function: |
promotes proliferation, migration, invasion and metabolic abilities; promotes tumor growth in vivo |
| Molecular mechanism: |
ceRNA mechanism: circ_0058124 sponges miR-940 to upregulate MAPK1 |
| Biological pathway or process: |
ceRNA regulation (promotes); proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); mitochondrial function (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Actinomycin D / DRB Stability Assay; Nuclear-Cytoplasmic Fractionation; Transfection; Colony Formation Assay; Transwell Assay; RIP (RNA Immunoprecipitation); RNA Pull-Down; Luciferase Reporter Assay; Western Blot; In Vivo Animal Model; Clinical Sample Validation; Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
circ_0058124 expression was related to TC tumor stage; associated with poor prognosis |
| Description: |
circ_0058124 is up-regulated in thyroid cancer tissues/cells and mainly localizes to the cytoplasm. It promotes TC cell proliferation, migration/invasion and metabolic capacity by sponging miR-940 to upregulate MAPK1, and its knockdown suppresses xenograft tumor growth. |
| Confidence score: |
0.8562 |