circRNA basic information
circBase ID: -
Name: hsa_circ_CTNND1
Synonym: circbeta‐catenin
Host Gene: beta‐catenin
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: cytoplasm
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005233
MONDO name: non-small cell lung carcinoma
Disease details: non-small cell lung cancer
Disease DO ID:
 3908
Disease MeSH ID:
 D002289
Disease NCIt ID:
 C2926
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

NSCLC tissues; paracancerous normal tissues
Cell lines:

BEAS‐2B; H1299; A549
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: GSK3beta, beta‐catenin
Associated microRNA: -
Biological function: promotes migration, invasion, and proliferation (malignant phenotypes) of NSCLC cells
Molecular mechanism: circbeta‐catenin encodes a peptide (circbeta‐catenin‐370aa) that binds GSK3beta, suppresses GSK3beta-mediated beta-catenin phosphorylation/ubiquitination, stabilizes beta-catenin protein, and activates Wnt/beta-catenin signaling
Biological pathway or process:

Wnt/beta-catenin (promotes); proliferation (promotes); migration (promotes); invasion (promotes); EMT (promotes); ubiquitination (inhibits)
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Colony Formation Assay; Wound Healing Assay; Transwell Assay; Western Blot; IF (Immunofluorescence); Co-IP
Clinical significance:

-
Description:

circbeta-catenin is up-regulated in NSCLC tissues/cells and promotes malignant phenotypes (proliferation, migration, invasion, EMT). It encodes a peptide (circbeta-catenin-370aa) that binds GSK3beta, reduces beta-catenin ubiquitination/degradation, and enhances Wnt/beta-catenin signaling.
Confidence score:

0.6285
Other information
Title:

Circular RNA circbeta-catenin aggravates the malignant phenotype of non-small-cell lung cancer via encoding a peptide.

Journal: Journal of clinical laboratory analysis
Published: 2021
PubMed ID: 34296778
Study type:

combined biological and clinical study
Data availability: All data are included in this article.
Code availability: -