| Expression pattern: |
UP |
| Associated gene: |
PRKACB |
| Associated microRNA: |
miR-206 |
| Biological function: |
Promotes AML cell proliferation, migration and invasion; inhibits apoptosis; promotes cell cycle progression. |
| Molecular mechanism: |
Acts as a miRNA sponge for miR-206 to upregulate PRKACB (ceRNA mechanism). |
| Biological pathway or process: |
ceRNA regulation (promotes); proliferation (promotes); apoptosis (inhibits); cell cycle (promotes); migration (promotes); invasion (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Transfection; CCK8; Colony Formation Assay; Annexin V/PI Flow Cytometry; Cell Cycle Assay; Transwell Assay; Western Blot; Luciferase Reporter Assay; Clinical Sample Validation; Bioinformatics Analysis |
| Clinical significance: |
circRAD18 might be a therapeutic target for AML. |
| Description: |
circRAD18 is up-regulated in AML patient blood and AML cell lines. It promotes malignant phenotypes (proliferation, migration/invasion, cell-cycle progression) and inhibits apoptosis by sponging miR-206, thereby increasing PRKACB expression (circRAD18/miR-206/PRKACB axis). |
| Confidence score: |
0.7181 |