| Expression pattern: |
UP |
| Associated gene: |
REXO1, AGO2 |
| Associated microRNA: |
miR-452-5p |
| Biological function: |
Promotes cervical cancer cell proliferation, migration, invasion, and tumor growth in vivo. |
| Molecular mechanism: |
Acts as a ceRNA: circ-CCDC66 sponges miR-452-5p, thereby relieving miR-452-5p repression of REXO1 and increasing REXO1 expression. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Nuclear-Cytoplasmic Fractionation; FISH / smFISH; RNA Pull-Down; RIP (RNA Immunoprecipitation); Luciferase Reporter Assay; Transfection; CCK8; Transwell Assay; Western Blot; In Vivo Animal Model; Clinical Sample Validation |
| Clinical significance: |
High expression of circ-CCDC66 was associated with later tumor stage and larger tumor size. |
| Description: |
circ-CCDC66 is upregulated in cervical cancer tissues and promotes proliferation, migration, invasion, and xenograft tumor growth. Mechanistically, it functions as a miRNA sponge for miR-452-5p to increase REXO1 expression, forming a circ-CCDC66/miR-452-5p/REXO1 axis. |
| Confidence score: |
0.7441 |