| Expression pattern: |
UP |
| Associated gene: |
FBXO22 |
| Associated microRNA: |
miR-155 |
| Biological function: |
promotes proliferation, migration, invasion and tumor growth of gastric cancer cells |
| Molecular mechanism: |
Acts as a ceRNA sponging miR-155 to upregulate FBXO22 expression |
| Biological pathway or process: |
ceRNA regulation (promotes); proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Back-Splice Junction PCR / divergent primers PCR; CCK8; Colony Formation Assay; Transwell Assay; Luciferase Reporter Assay; Western Blot; Nuclear-Cytoplasmic Fractionation; Transfection; Clinical Sample Validation; In Vivo Animal Model; IHC (Immunohistochemistry) |
| Clinical significance: |
Over-expression of circ_0006282 was associated with tumor size, lymph nodes metastasis and TNM stage |
| Description: |
circ_0006282 is up-regulated in gastric cancer tissues and cell lines and promotes malignant behaviors (proliferation, migration/invasion, and xenograft growth). Mechanistically, it mainly localizes in the cytoplasm and functions as a ceRNA that sponges miR-155, thereby upregulating FBXO22 to drive GC progression. |
| Confidence score: |
0.8034 |