| Expression pattern: |
UP |
| Associated gene: |
VEGFA, AGO2 |
| Associated microRNA: |
miR-29c-3p |
| Biological function: |
promotes CRC cell proliferation, invasion/metastasis and angiogenesis; promotes tumor growth in vivo |
| Molecular mechanism: |
Acts as a ceRNA/miRNA sponge for miR-29c-3p to relieve repression of VEGFA; AGO2-associated binding confirmed |
| Biological pathway or process: |
proliferation (promotes); invasion (promotes); angiogenesis (promotes); ceRNA regulation (promotes); VEGF/VEGFR (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RNase R Treatment; RT-qPCR; Clinical Sample Validation; Survival Analysis; ROC Analysis; Transfection; MTT; EdU Staining; Transwell Assay; Tube Formation Assay; Western Blot; IHC (Immunohistochemistry); H&E Staining; RIP (RNA Immunoprecipitation); Luciferase Reporter Assay; In Vivo Animal Model |
| Clinical significance: |
High circ-001971 expression was related to advanced TNM stages, lymphatic metastasis, and adverse prognosis; ROC analysis indicated potential diagnostic and prognostic capability in CRC. |
| Description: |
circ-001971 is up-regulated in colorectal cancer tissues/cell lines and promotes proliferation, invasion/metastasis-related behavior and angiogenesis. Mechanistically, it functions as a ceRNA that binds miR-29c-3p in an AGO2-associated manner, relieving miR-29c-3p-mediated repression of VEGFA; higher circ-001971 correlates with advanced stage and poorer overall survival. |
| Confidence score: |
0.8154 |