circRNA basic information
circBase ID: hsa_circ_0010023
Name: hsa_circ_DHRS3
Synonym: hsa_-circ_0010023
Host Gene: DHRS3
Genomic location(hg19): chr1:12638745-12639440:-
Genomic location(hg38): chr1:12578717-12579412:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005075
MONDO name: thyroid gland papillary carcinoma
Disease details: Papillary thyroid carcinoma
Disease DO ID:
 3969
Disease MeSH ID:
 -
Disease NCIt ID:
 C4035
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

PTC carcinoma; adjacent normal tissues; tumor tissue; paired adjacent normal tissues
Cell lines:

K1
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: MAPK1
Associated microRNA: miR-1250-5p
Biological function: Promotes PTC cell proliferation, inhibits apoptosis, and is associated with lymph node metastasis and extrathyroid infiltration.
Molecular mechanism: hsa_circ_0010023 may act as a miRNA sponge for miR-1250-5p and regulate MAPK1 expression in PTC.
Biological pathway or process:

proliferation (promotes); apoptosis (inhibits); metastasis (promotes); invasion (promotes); ceRNA regulation (other); MAPK (promotes)
Detected method:
Q
Validation methods:

Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; Sanger Sequencing; RT-qPCR; Clinical Sample Validation; Luciferase Reporter Assay; Transfection; CCK8; Annexin V/PI Flow Cytometry; ROC Analysis; Bioinformatics Analysis
Clinical significance:

hsa_circ_0010023 was correlated with lymph node metastasis and extrathyroid infiltration, had diagnostic potential for PTC, and may be a potential biomarker/tumor marker for PTC diagnosis.
Description:

hsa_circ_0010023 is up-regulated in PTC tissues and is associated with lymph node metastasis and extrathyroid infiltration. Functional knockdown experiments in K1 cells indicate that it promotes proliferation and inhibits apoptosis. Mechanistically, it may sponge miR-1250-5p and regulate MAPK1, supporting its potential role as a diagnostic biomarker for PTC.
Confidence score:

0.8078
Other information
Title:

Hsa_circ_0010023 promotes the development of papillary thyroid carcinoma by sponging miR-1250-5p.

Journal: Endocrine
Published: 2024
PubMed ID: 38914746
Study type:

combined biological and clinical study
Data availability: The data used to support the findings of this study are available from the corresponding author upon request; supplementary material available at https://doi.org/10.1007/s12020-024-03936-8
Code availability: -