| Expression pattern: |
UP |
| Associated gene: |
EZH2 |
| Associated microRNA: |
miR-214-3p |
| Biological function: |
promotes HCC cell proliferation, invasion and migration; inhibits apoptosis; promotes tumor growth in vivo |
| Molecular mechanism: |
Acts as a miRNA sponge for miR-214-3p, thereby increasing EZH2 expression |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Western Blot; Luciferase Reporter Assay; Transfection; CCK8; Wound Healing Assay; Annexin V/PI Flow Cytometry; In Vivo Animal Model; Bioinformatics Analysis; Clinical Sample Validation |
| Clinical significance: |
hsa_circ_0008450 might be a potential biomarker for HCC diagnosis and prognosis |
| Description: |
hsa_circ_0008450 is up-regulated in HCC tissues and cell lines and functions as an oncogenic circRNA. It sponges miR-214-3p to increase EZH2 expression, thereby promoting proliferation/migration/invasion and inhibiting apoptosis; its knockdown suppresses tumor growth in a Huh-7 xenograft model. |
| Confidence score: |
0.6536 |