| Expression pattern: |
UP |
| Associated gene: |
- |
| Associated microRNA: |
miR-1183 |
| Biological function: |
Promotes proliferation, migration and invasion and inhibits apoptosis; reduces radiosensitivity (promotes radioresistance) in glioma. |
| Molecular mechanism: |
Acts as a ceRNA/miRNA sponge by directly binding miR-1183, negatively regulating miR-1183. |
| Biological pathway or process: |
proliferation (promotes); apoptosis (inhibits); migration (promotes); invasion (promotes); radioresistance (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis; Luciferase Reporter Assay; RNA Pull-Down; Transfection; CCK8; Annexin V/PI Flow Cytometry; Wound Healing Assay; Transwell Assay |
| Clinical significance: |
Higher circ_VCAN expression in radioresistant glioma tissues than in radiosensitive tissues. |
| Description: |
circ_VCAN (hsa_circ_0073237; host gene VCAN) is upregulated in radioresistant glioma tissues and promotes radioresistance-associated malignant phenotypes. Mechanistically, it directly binds/sponges miR-1183 to negatively regulate miR-1183, thereby enhancing proliferation, migration and invasion while suppressing apoptosis after irradiation. |
| Confidence score: |
0.7032 |