| Expression pattern: |
UP |
| Associated gene: |
TEAD1, PTCH1, LOX |
| Associated microRNA: |
miR-1287-5p |
| Biological function: |
promotes proliferation, migration and invasion; inhibits apoptosis in HCC cells |
| Molecular mechanism: |
circ-CCT3 acts as a miRNA sponge for miR-1287-5p to upregulate TEAD1; TEAD1 transcriptionally activates PTCH1 and LOX |
| Biological pathway or process: |
proliferation (promotes); apoptosis (inhibits); migration (promotes); invasion (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; RNase R Treatment; Nuclear-Cytoplasmic Fractionation; Luciferase Reporter Assay; Transfection; CCK8; Colony Formation Assay; Annexin V/PI Flow Cytometry; Flow Cytometry（Non-apoptosis/cycle）; Wound Healing Assay; Transwell Assay; Western Blot; ChIP / ChIP-seq; Bioinformatics Analysis; Clinical Sample Validation; Cohort Study; Survival Analysis |
| Clinical significance: |
High circ-CCT3 expression was linked to a worse overall survival rate after surgical resection. |
| Description: |
circ-CCT3 is upregulated in HCC and promotes proliferation, migration/invasion while inhibiting apoptosis. Mechanistically, it sponges miR-1287-5p to increase TEAD1, which activates PTCH1 and LOX transcription, and high circ-CCT3 predicts worse overall survival. |
| Confidence score: |
0.8427 |