circRNA basic information
circBase ID: hsa_circ_0001283
Name: hsa_circ_HIPK3
Synonym: circRNA-001283
Host Gene: HIPK3
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: cytoplasm
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007254
MONDO name: breast cancer
Disease details: breast cancer
Disease DO ID:
 1612
Disease MeSH ID:
 -
Disease NCIt ID:
 C9335
Disease ICD11 ID:
 1047754165
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

breast cancer tissues; adjacent non-cancer tissues
Cell lines:

MCF-7; MDA-MB-231; MDA-MB-468; MDA-MB-453; MCF-10A; HEK293T
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: HIPK3, p65, p50
Associated microRNA: miR-187
Biological function: Suppresses breast cancer cell growth/proliferation and invasion, and promotes apoptosis.
Molecular mechanism: Acts as a ceRNA sponge for miR-187 to positively regulate HIPK3 and thereby modulate NF-kappaB signaling (p65/p50).
Biological pathway or process:

NF-kappaB (inhibits); proliferation (inhibits); invasion (inhibits); apoptosis (promotes); ceRNA regulation (other)
Detected method:
Q
H
M
Validation methods:

Microarray; RT-qPCR; FISH / smFISH; Luciferase Reporter Assay; Transfection; CCK8; Annexin V/PI Flow Cytometry; Transwell Assay; Western Blot; Bioinformatics Analysis; Clinical Sample Validation
Clinical significance:

-
Description:

circRNA-0001283 is down-regulated in breast cancer tissues/cells and acts as a tumor suppressor. It sponges miR-187 to upregulate HIPK3 and suppress NF-kappaB signaling, thereby inhibiting proliferation/invasion and promoting apoptosis.
Confidence score:

0.6956
Other information
Title:

Circular RNA-0001283 Suppresses Breast Cancer Proliferation and Invasion via MiR-187/HIPK3 Axis.

Journal: Medical science monitor : international medical journal of experimental and clinical research
Published: 2020
PubMed ID: 32066649
Study type:

combined biological and clinical study
Data availability: Data used to support our findings in this study are available from the corresponding author upon request.
Code availability: -