| Expression pattern: |
UP |
| Associated gene: |
- |
| Associated microRNA: |
miR-143 |
| Biological function: |
promotes hepatocellular carcinoma cell proliferation and inhibits apoptosis; associated with pathological stage and poor prognosis |
| Molecular mechanism: |
circ_0000064 binds and regulates microRNA-143; circ_0000064 inhibits microRNA-143 expression, thereby promoting proliferation and inhibiting apoptosis of hepatocellular carcinoma cells |
| Biological pathway or process: |
proliferation (promotes); apoptosis (inhibits); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Colony Formation Assay; Annexin V/PI Flow Cytometry; Luciferase Reporter Assay; Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
high expression was positively correlated with pathological stage and poor prognosis of hepatocellular carcinoma |
| Description: |
circ_0000064 is up-regulated in hepatocellular carcinoma tissues and cell lines. High circ_0000064 expression is associated with advanced pathological stage and poor prognosis, and functionally it promotes HCC cell proliferation while inhibiting apoptosis. Mechanistically, circ_0000064 interacts with and suppresses microRNA-143. |
| Confidence score: |
0.7078 |