| Expression pattern: |
DN |
| Associated gene: |
SCAI / Suppressor of Cancer Cell Invasion, AGO2 |
| Associated microRNA: |
miR-1270 |
| Biological function: |
sensitizes ovarian cancer cells to cisplatin, inhibits proliferation, promotes cisplatin-induced apoptosis, and reduces migration |
| Molecular mechanism: |
Cdr1as functions as a molecular sponge of miR-1270 to relieve miR-1270-mediated repression of SCAI |
| Biological pathway or process: |
chemoresistance (inhibits); proliferation (inhibits); apoptosis (promotes); migration (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Transfection; CCK8; Annexin V/PI Flow Cytometry; Transwell Assay; In Vivo Animal Model; Western Blot; IHC (Immunohistochemistry) |
| Clinical significance: |
exosomal Cdr1as in serum is lower in cisplatin-resistant patients and may serve as a biomarker for cisplatin-resistant ovarian cancer |
| Description: |
Cdr1as is down-regulated in cisplatin-resistant ovarian cancer tissues/cells and in serum exosomes from cisplatin-resistant patients. Functionally, Cdr1as increases cisplatin chemosensitivity by acting as a ceRNA sponge for miR-1270, thereby restoring SCAI expression to inhibit malignant phenotypes and reduce cisplatin resistance. |
| Confidence score: |
0.7756 |