| Expression pattern: |
UP |
| Associated gene: |
- |
| Associated microRNA: |
- |
| Biological function: |
Potential involvement in NSCLC onset or progression; higher serum levels associated with lymph node metastasis, poor differentiation, advanced TNM stage; prognostic and diagnostic biomarker. |
| Molecular mechanism: |
- |
| Biological pathway or process: |
not specified |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; Clinical Sample Validation; ROC Analysis; Survival Analysis |
| Clinical significance: |
Serum circRNA_001846 differentiates NSCLC patients from controls (AUC 0.872); high serum levels associated with lymph node metastasis, poor differentiation and advanced TNM stage; higher levels linked to reduced PFS and OS. |
| Description: |
circRNA_001846 is up-regulated in NSCLC (tumor tissue by microarray and patient serum by RT-qPCR). High serum circRNA_001846 is associated with adverse clinicopathological features and poorer PFS/OS, and it shows good diagnostic performance for distinguishing NSCLC from healthy controls. |
| Confidence score: |
0.5202 |