| Expression pattern: |
DN |
| Associated gene: |
TIF1gamma, AGO2, Snail |
| Associated microRNA: |
miR-429, miR-200b-3p |
| Biological function: |
Inhibits TGF-beta-induced EMT, migration/invasion, and metastasis in NSCLC; promotes TIF1gamma expression. |
| Molecular mechanism: |
Acts as a miRNA sponge for miR-429/miR-200b-3p to protect TIF1gamma from miRNA-mediated repression; attenuates TGF-beta/Smad signaling output (e.g., Snail). |
| Biological pathway or process: |
EMT (inhibits); invasion (inhibits); metastasis (inhibits); TGF-beta/SMAD (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
B
M
|
| Validation methods: |
Microarray; RT-qPCR; Northern Blot; Back-Splice Junction PCR / divergent primers PCR; Sanger Sequencing; RNase R Treatment; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); RNA Pull-Down; FISH / smFISH; Transfection; Transwell Assay; In Vivo Animal Model; H&E Staining; Clinical Sample Validation; Bioinformatics Analysis |
| Clinical significance: |
circPTK2 expression is down-regulated in human NSCLC tissues and is significantly lower in metastatic NSCLC tissues than non-metastatic counterparts; positively correlated with TIF1gamma expression. |
| Description: |
In NSCLC, circPTK2 (hsa_circ_0008305) is down-regulated during TGF-beta-induced EMT and in patient tumors, especially metastatic tissues. It suppresses EMT, invasion, and metastasis by sponging miR-429/miR-200b-3p to relieve repression of TIF1gamma, thereby dampening TGF-beta/Smad signaling output such as Snail. |
| Confidence score: |
0.8491 |