| Expression pattern: |
UP |
| Associated gene: |
FOXQ1, AGO2 |
| Associated microRNA: |
miR-422a |
| Biological function: |
Promotes NPC cell migration, invasion, metastasis, EMT and docetaxel chemoresistance. |
| Molecular mechanism: |
Acts as a ceRNA/miRNA sponge: circCRIM1 binds miR-422a to relieve repression of FOXQ1, thereby promoting metastasis, EMT and docetaxel chemoresistance. |
| Biological pathway or process: |
migration (promotes); invasion (promotes); metastasis (promotes); EMT (promotes); ceRNA regulation (promotes); chemoresistance (promotes) |
| Detected method: |
Q
S
|
| Validation methods: |
RNA-seq; RNase R Treatment; divergent primers PCR; Sanger Sequencing; RT-qPCR; Clinical Sample Validation; Nuclear-Cytoplasmic Fractionation; FISH / smFISH; RIP (RNA Immunoprecipitation); Luciferase Reporter Assay; RNA Pull-Down; Transfection; Transwell Assay; CCK8; Colony Formation Assay; Western Blot; IF (Immunofluorescence); In Vivo Animal Model; H&E Staining; IHC (Immunohistochemistry); ROC Analysis; Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
High circCRIM1 expression is associated with unfavorable survival and is an independent prognostic indicator; a model combining circCRIM1 expression and N stage predicts distant metastasis risk and response to docetaxel-containing induction chemotherapy. |
| Description: |
circCRIM1 (hsa_circ_0002346) is upregulated in nasopharyngeal carcinoma, especially in patients/cells with high metastatic potential. It promotes metastasis/EMT and docetaxel chemoresistance by sponging miR-422a and derepressing FOXQ1, and high expression predicts poor survival and reduced benefit from docetaxel-containing induction chemotherapy. |
| Confidence score: |
0.8942 |