| Expression pattern: |
UP |
| Associated gene: |
EGFR, CCNE1, PIK3CD, Ki-67 |
| Associated microRNA: |
miR-7 |
| Biological function: |
Promotes tumor progression and cell growth/proliferation; inhibits apoptosis; promotes G1/S cell-cycle progression in NSCLC. |
| Molecular mechanism: |
Acts as a miR-7 sponge (ceRNA) to up-regulate miR-7 target genes (EGFR, CCNE1, PIK3CD), antagonizing miR-7 tumor-suppressive effects. |
| Biological pathway or process: |
ceRNA regulation (promotes); proliferation (promotes); apoptosis (inhibits); cell cycle (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Annexin V/PI Flow Cytometry; Cell Cycle Assay; Western Blot; IHC (Immunohistochemistry); In Vivo Animal Model; Survival Analysis; Luciferase Reporter Assay; Bioinformatics Analysis |
| Clinical significance: |
High CDR1as expression is associated with higher TNM stage, lymph node metastasis, and shorter overall survival; CDR1as is an independent prognostic factor in NSCLC. |
| Description: |
CDR1as is up-regulated in NSCLC and acts as an oncogenic circRNA. It sponges miR-7, thereby up-regulating miR-7 targets (EGFR, CCNE1, PIK3CD) to promote proliferation/cell growth and inhibit apoptosis, and its high expression predicts poorer overall survival. |
| Confidence score: |
0.7408 |