| Expression pattern: |
DN |
| Associated gene: |
PTEN, AKT |
| Associated microRNA: |
miR-23a-3p |
| Biological function: |
enhances radiosensitivity; suppresses proliferation and colony formation/survival fraction; induces apoptosis; induces cell-cycle arrest |
| Molecular mechanism: |
ceRNA sponge of miR-23a-3p to relieve inhibition of PTEN and inactivate AKT signaling |
| Biological pathway or process: |
proliferation (inhibits); apoptosis (promotes); cell cycle (other); PI3K/AKT (inhibits); ceRNA regulation (other); radioresistance (inhibits) |
| Detected method: |
Q
H
S
|
| Validation methods: |
RNA-seq; RT-qPCR; Sanger Sequencing; RNase R Treatment; divergent primers PCR; FISH / smFISH; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis; RIP (RNA Immunoprecipitation); Luciferase Reporter Assay; Transfection; MTT; Colony Formation Assay; Annexin V/PI Flow Cytometry; Cell Cycle Assay; Western Blot |
| Clinical significance: |
ROC curves were highly discriminative between OSCC patients and ANCT (AUC 0.711); circATRNL1 expression was associated with pathological differentiation, lymph node metastasis, and clinical stage |
| Description: |
circATRNL1 is down-regulated in OSCC tissues and cell lines and further decreases after irradiation. Forced upregulation of circATRNL1 sensitizes OSCC cells to irradiation by inhibiting proliferation/colony survival, promoting apoptosis, and inducing G2 arrest, mainly via a ceRNA mechanism (circATRNL1→miR-23a-3p→PTEN) that suppresses AKT signaling. |
| Confidence score: |
0.8632 |