circRNA basic information
circBase ID: -
Name: mmu_circ_Cdr1as
Synonym: Cdr1as / CiRS-7
Host Gene: Cdr1as
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005068
MONDO name: myocardial infarction
Disease details: myocardial infarction
Disease DO ID:
 5844
Disease MeSH ID:
 D009203
Disease NCIt ID:
 C27996
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Mouse
Species details: Mus musculus
Tissue specimen:

myocardial tissues; heart tissues
Cell lines:

MCM
In vivo animal model:

other disease animal model
circRNA-disease information
Expression pattern:
UP
Associated gene: PARP, SP1
Associated microRNA: miR-7a
Biological function: Promotes cardiomyocyte apoptosis and aggravates myocardial infarction injuries (increases infarct size), via inhibiting the protective effect of miR-7a.
Molecular mechanism: Acts as a miR-7a sponge, reducing miR-7a activity and thereby increasing expression of miR-7a target genes PARP and SP1.
Biological pathway or process:

apoptosis (promotes); ceRNA regulation (promotes)
Detected method:
Q
Validation methods:

RT-qPCR; Transfection; Luciferase Reporter Assay; Western Blot; Annexin V/PI Flow Cytometry; In Vivo Animal Model; IHC (Immunohistochemistry)
Clinical significance:

-
Description:

Cdr1as is up-regulated in mouse myocardial infarction and in hypoxia-treated cardiomyocytes. It promotes cardiomyocyte apoptosis and worsens MI injury by sponging miR-7a, thereby relieving miR-7a-mediated repression of PARP and SP1.
Confidence score:

0.6216
Other information
Title:

The Circular RNA Cdr1as Promotes Myocardial Infarction by Mediating the Regulation of miR-7a on Its Target Genes Expression.

Journal: PloS one
Published: 2016
PubMed ID: 26998750
Study type:

biological research
Data availability: -
Code availability: -