| Expression pattern: |
UP |
| Associated gene: |
HIF-1alpha |
| Associated microRNA: |
miR-338-3p |
| Biological function: |
Promotes cervical cancer cell growth, migration/invasion and EMT; inhibits apoptosis. |
| Molecular mechanism: |
Acts as a ceRNA sponge for miR-338-3p, thereby up-regulating HIF-1alpha and promoting HIF-1alpha-mediated EMT. |
| Biological pathway or process: |
EMT (promotes); proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis; Luciferase Reporter Assay; RNA Pull-Down; Transfection; CCK8; Colony Formation Assay; Annexin V/PI Flow Cytometry; Transwell Assay; Western Blot |
| Clinical significance: |
- |
| Description: |
circ-HIPK3 is up-regulated in cervical cancer tissues/cell lines and promotes malignant phenotypes including proliferation, migration/invasion and EMT while inhibiting apoptosis. Mechanistically, it sponges miR-338-3p to relieve repression of HIF-1alpha, forming a circ-HIPK3/miR-338-3p/HIF-1alpha axis. |
| Confidence score: |
0.7045 |