| Expression pattern: |
UP |
| Associated gene: |
Ago2, PI3K/AKT signaling pathway, Cyclin A1, Cyclin B1, p-AKT |
| Associated microRNA: |
miR-188-3p |
| Biological function: |
promotes NSCLC progression and proliferation (in vitro and in vivo) |
| Molecular mechanism: |
Acts as a ceRNA/miRNA sponge for miR-188-3p, affecting PI3K/AKT signaling and proliferation-related genes (Cyclin A1, Cyclin B1). |
| Biological pathway or process: |
PI3K/AKT (promotes); proliferation (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Clinical Sample Validation; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Transfection; CCK8; Colony Formation Assay; Western Blot; In Vivo Animal Model; H&E Staining; Bioinformatics Analysis |
| Clinical significance: |
potential diagnostic biomarker and therapeutic target for NSCLC |
| Description: |
circGFRA1 is up-regulated in NSCLC tissues and promotes NSCLC cell/tumor proliferation. It functions as a ceRNA by sponging miR-188-3p and activates PI3K/AKT signaling, with downstream increases in proliferation-associated factors (eg, Cyclin A1 and Cyclin B1). |
| Confidence score: |
0.7591 |