| Expression pattern: |
DN |
| Associated gene: |
ZIC1, beta-catenin, cyclin D1, c-myc, E-cadherin, N-cadherin, Vimentin, MMP2 |
| Associated microRNA: |
miR-541-5p |
| Biological function: |
suppresses HCC cell proliferation, migration and invasion, and promotes apoptosis; suppresses tumor growth in vivo |
| Molecular mechanism: |
ceRNA mechanism: circMTO1 sponges miR-541-5p to relieve repression of ZIC1, thereby regulating Wnt/beta-catenin signaling and EMT markers |
| Biological pathway or process: |
Wnt/beta-catenin (inhibits); EMT (inhibits); proliferation (inhibits); migration (inhibits); invasion (inhibits); apoptosis (promotes); ceRNA regulation (other) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; Clinical Sample Validation; RNA Pull-Down; Luciferase Reporter Assay; Bioinformatics Analysis; Transfection; CCK8; Transwell Assay; Annexin V/PI Flow Cytometry; Western Blot; In Vivo Animal Model; IHC (Immunohistochemistry); H&E Staining |
| Clinical significance: |
- |
| Description: |
circMTO1 is down-regulated in HCC and acts as a tumor suppressor. It sponges miR-541-5p to derepress ZIC1, thereby inhibiting Wnt/beta-catenin signaling and EMT and reducing proliferation, migration, invasion while promoting apoptosis, including in a xenograft model. |
| Confidence score: |
0.7759 |