| Expression pattern: |
UP |
| Associated gene: |
CHD9 |
| Associated microRNA: |
miR-197-5p |
| Biological function: |
promotes proliferation and migration and tumor growth in gastric cancer |
| Molecular mechanism: |
Acts as a ceRNA/miRNA sponge for miR-197-5p to upregulate CHD9 (miR-197-5p/CHD9 axis). |
| Biological pathway or process: |
ceRNA regulation (promotes); proliferation (promotes); migration (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Nuclear-Cytoplasmic Fractionation; Luciferase Reporter Assay; Transfection; MTT; Colony Formation Assay; Transwell Assay; Western Blot; In Vivo Animal Model; Clinical Sample Validation; Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
High circPDZD8 levels are associated with shorter overall survival in gastric cancer patients. |
| Description: |
circPDZD8 is up-regulated in gastric cancer and mainly localized in the cytoplasm. It promotes gastric cancer cell proliferation and migration and tumor growth by acting as a ceRNA that sponges miR-197-5p, thereby increasing CHD9 expression via the miR-197-5p/CHD9 axis. High circPDZD8 expression is associated with poorer overall survival. |
| Confidence score: |
0.7369 |