| Expression pattern: |
UP |
| Associated gene: |
USP25 |
| Associated microRNA: |
hsa-miR-20b-3p, hsa-miR-93-3p, hsa-miR-370-3p, hsa-miR-520d-3p, hsa-miR-651-3p |
| Biological function: |
may contribute to DS pathogenesis and serve as a non-invasive prenatal biomarker |
| Molecular mechanism: |
predicted miRNA sponge (MREs) and circRNA-miRNA-mRNA interaction network affecting diploid gene expression balance; linked to USP25 dosage imbalance |
| Biological pathway or process: |
ceRNA regulation (other) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis |
| Clinical significance: |
hsa_circRNA_103112 in peripheral blood of a pregnant woman may serve as potential biomarker of fetal DS during non-invasive prenatal screening |
| Description: |
hsa_circRNA_103112 is upregulated in DS in both umbilical cord blood and peripheral blood. It is predicted to act as a miRNA sponge (hsa-miR-20b-3p/93-3p/370-3p/520d-3p/651-3p) within a circRNA-miRNA-mRNA interaction network and is linked to the host gene USP25, suggesting involvement in DS pathogenesis and potential use as a non-invasive prenatal blood biomarker. |
| Confidence score: |
0.4032 |