| Expression pattern: |
UP |
| Associated gene: |
- |
| Associated microRNA: |
miR-181b |
| Biological function: |
prognostic biomarker (higher plasma level associated with longer overall survival); diagnostic biomarker for advanced CRC and stage III vs stage IV differentiation |
| Molecular mechanism: |
possible miRNA sponge interaction with miR-181b (trend only; no significant correlation) |
| Biological pathway or process: |
ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Clinical Sample Validation; ROC Analysis; Survival Analysis; Cohort Study |
| Clinical significance: |
Low plasma levels associated with shorter overall survival; prognostic marker for metastatic CRC; can distinguish stage III from stage IV (ROC) |
| Description: |
hsa_circ_0001445 is up-regulated in plasma from advanced CRC patients and shows diagnostic value. In metastatic CRC, higher plasma hsa_circ_0001445 is associated with longer overall survival, supporting its prognostic biomarker potential. The study explored a possible miRNA-sponge relationship with miR-181b but found only a weak trend without significant correlation. |
| Confidence score: |
0.5918 |