| Expression pattern: |
DS |
| Associated gene: |
PPARgamma, MMP-9, PPARGC1B, PDK1, AR |
| Associated microRNA: |
miR-125b-2-3p, miR-4736 |
| Biological function: |
promotes cell invasion and metastasis in prostate cancer under Enzalutamide/AR suppression; modulates bladder cancer invasion via the same axis |
| Molecular mechanism: |
AR transcriptional autoregulation alters circRNA-ARC1 level; circRNA-ARC1 sponges miR-125b-2-3p and miR-4736, releasing PPARGC1B/PDK1 and activating PPARgamma-driven MMP-9 expression to regulate invasion/metastasis |
| Biological pathway or process: |
invasion (promotes); metastasis (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Transfection; Transwell Assay; RNA Pull-Down; Luciferase Reporter Assay; In Vivo Animal Model; H&E Staining; IHC (Immunohistochemistry); Bioinformatics Analysis |
| Clinical significance: |
- |
| Description: |
circRNA-ARC1 is an AR-locus-derived circRNA whose level is differentially regulated by AR/Enzalutamide in prostate vs bladder cancer cells. It promotes invasion/metastasis by sponging miR-125b-2-3p and miR-4736, thereby modulating PPARGC1B/PDK1 and downstream PPARgamma-driven MMP-9 signaling; knocking down circRNA-ARC1 suppresses Enz-induced prostate cancer metastasis in vivo. |
| Confidence score: |
0.7551 |