circRNA basic information
circBase ID: hsa_circ_0000977
Name: hsa_circ_NOL10
Synonym: -
Host Gene: NOL10
Genomic location(hg19): chr2:10784445-10808849:-
Genomic location(hg38): chr2:10644319-10668723:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007254
MONDO name: breast cancer
Disease details: breast cancer
Disease DO ID:
 1612
Disease MeSH ID:
 -
Disease NCIt ID:
 C9335
Disease ICD11 ID:
 1047754165
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

BC tissue specimens; paired adjacent normal tissue specimens
Cell lines:

MCF-7; MDA-MB-231; MCF-10A
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: -
Associated microRNA: -
Biological function: May serve a role in BC tumorigenesis as a transcriptional regulator (based on ceRNA network and enrichment analyses).
Molecular mechanism: ceRNA mechanism (predicted miRNA sponging) with downstream target mRNAs inferred by bioinformatics; MAPK pathway enrichment among predicted targets.
Biological pathway or process:

MAPK (other); ceRNA regulation (other)
Detected method:
Q
M
Validation methods:

Microarray; RT-qPCR; divergent primers PCR; Sanger Sequencing; Clinical Sample Validation
Clinical significance:

Potential diagnostic biomarkers for patients with BC (suggested).
Description:

hsa_circ_0000977 is down-regulated in breast cancer tissues and cell lines. The paper predicts it participates in a ceRNA network, and enrichment analysis highlights MAPK signaling among pathways associated with its predicted targets.
Confidence score:

0.5541
Other information
Title:

Analysis of circular RNA-associated competing endogenous RNA network in breast cancer.

Journal: Oncology letters
Published: 2020
PubMed ID: 32002039
Study type:

combined biological and clinical study
Data availability: GSE101124
Code availability: -