| Expression pattern: |
UP |
| Associated gene: |
SGPP1, CyclinD1, Caspase-3 |
| Associated microRNA: |
miR-525-5p |
| Biological function: |
circ_0000423 promotes CRC cell proliferation, migration, invasion and tumorigenesis, inhibits apoptosis, and counteracts the inhibitory effects of sevoflurane on CRC progression. |
| Molecular mechanism: |
circ_0000423 functions as a ceRNA by sponging miR-525-5p to positively regulate SGPP1 expression, thereby mediating sevoflurane-regulated CRC progression. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); ceRNA regulation (other); other pathway/process (promotes) |
| Detected method: |
Q
|
| Validation methods: |
Back-Splice Junction PCR / divergent primers PCR; RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Transfection; CCK8; Colony Formation Assay; Annexin V/PI Flow Cytometry; Transwell Assay; Western Blot; In Vivo Animal Model; IHC (Immunohistochemistry) |
| Clinical significance: |
circ_0000423 was upregulated in CRC tumor tissues and was proposed as an effective therapeutic target for CRC. |
| Description: |
circ_0000423 is upregulated in colorectal cancer tissues and cells and is reduced by sevoflurane treatment. Functionally, circ_0000423 promotes CRC proliferation, migration, invasion and tumor growth while suppressing apoptosis, mainly through the circ_0000423/miR-525-5p/SGPP1 ceRNA axis. Overexpression of circ_0000423 weakens the anti-tumor effects of sevoflurane, suggesting its potential relevance as a therapeutic target in CRC. |
| Confidence score: |
0.8005 |