circRNA basic information
circBase ID: -
Name: -
Synonym: hsa-circRNA_003251
Host Gene: -
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005148
MONDO name: type 2 diabetes mellitus
Disease details: type 2 diabetes mellitus
Disease DO ID:
 9352
Disease MeSH ID:
 D003924
Disease NCIt ID:
 C26747
Disease ICD11 ID:
 119724091
Disease OMIM ID:
 125853
Species: Human
Species details: Homo sapiens
Tissue specimen:

whole blood
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: mRNAs
Associated microRNA: hsa-miR-4753-3p, hsa-miR-301a-5p, hsa-miR-3191-5p, hsa-miR-6805-5p, hsa-miR-761
Biological function: unknown
Molecular mechanism: May function as a miRNA sponge in a predicted circRNA/miRNA/mRNA network.
Biological pathway or process:

ceRNA regulation (other); MAPK (other); thyroid hormone (other); Wnt/beta-catenin (other); EGFR (other)
Detected method:
Q
M
Validation methods:

Microarray; RNase R Treatment; RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis
Clinical significance:

-
Description:

hsa-circRNA_003251 is up-regulated in whole blood of T2DM patients with depression versus T2DM without depression, validated by RT-qPCR. It is proposed to act within a predicted circRNA/miRNA/mRNA network (miRNA sponge/ceRNA) and is linked by KEGG prediction to thyroid hormone, Wnt, ErbB and MAPK signaling pathways.
Confidence score:

0.5135
Other information
Title:

Relationships of circular RNA with diabetes and depression.

Journal: Scientific reports
Published: 2017
PubMed ID: 28779132
Study type:

combined biological and clinical study
Data availability: The data in this article is available.
Code availability: -